She’s Struggling With a Mental Health Problem If sex is no longer on the table in your relationship, or if intimate moments have started to feel distant, this can be a sign that your girlfriend isn’t interested in growing your relationship any further. However, one partner losing interest in sex shouldn’t always be interpreted as a sign of trouble. It could simply mean that your partner is experiencing stress or other conditions that are affecting their desire for sex. It might also mean that your partner feels as though the quality of sex has declined. You’re Always Fighting When your girlfriend always finds a reason to get upset at something you did/didn’t do, if you’re constantly bickering, or if you can’t seem to do anything right in her eyes, this is never a good sign for a relationship. A relationship under constant conflict, no matter the efforts made to fix things, could be a strong signal that your girlfriend resents you.